Mesenchymal Stem Cells as Anti-inflammatory Agents

Created by: Pete Shuster on

StemTrophin Can Dampen Inflammatory Pain

Our StemTrophin Activates your Mesenchymal Stem Cells. Why does this matter? The properties of the cells include the power to act as anti-inflammatories; hence, they can dampen inflammation related pain AND awaken systems to optimize healing, cellular regeneration and functionality. The science behind this is solid. The authors of Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation (Joo, Youn Oh et al.) Molecular Therapy (2012); 20 1, 14–20. doi:10.1038/mt.2011.211 concluded: "The role of MSCs as guardians against excessive inflammation explains many of the beneficial effects observed with administration of the cells in animal models".

Summary of some of the anti-inflammatory effects of mesenchymal stem/stromal cells (MSCs). (1) Damage-associated molecular patterns (DAMPs) and interleukin (IL)-1α released by sterile injury or pathogen-associated molecular patterns (PAMPs) released by infectious injury to tissues activate resident macrophages through receptors involving pattern recognition receptors (PRRs). (2) The activated macrophages produce proinflammatory cytokines such as IL-1α, IL-1β, or tumor necrosis factor-α (TNF-α) to initiate the inflammatory cascade. (3) Simultaneously, the proinflammatory cytokines and probably other signals from injured cells activate MSCs to secrete anti-inflammatory factors that include TNF-α stimulated gene/protein 6 (TSG-6), PGE2, and IL-1ra that either modulate the activation of the resident macrophages or decrease the downstream effects of the proinflammatory cytokines. (4) The net effect is to decrease the amplification of the proinflammatory signals by parenchymal cells through the secretion of IL-6, CXCL1, and related factors and as a result to decrease the recruitment of neutrophils. Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation.Darwin J Prockop and Joo Youn Oh.

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